Fatal outcome of human coronavirus NL63 infection despite successful viral elimination by IFN‐alpha in a patient with newly diagnosed ALL
Identifieur interne : 001471 ( Main/Exploration ); précédent : 001470; suivant : 001472Fatal outcome of human coronavirus NL63 infection despite successful viral elimination by IFN‐alpha in a patient with newly diagnosed ALL
Auteurs : Karin Mayer [Allemagne] ; Cordula Nellessen [Allemagne] ; Corinna Hahn-Ast [Allemagne] ; Martin Schumacher [Allemagne] ; Sandra Pietzonka [Allemagne] ; Anna M. Eis-Hübinger [Allemagne] ; Christian Drosten [Allemagne] ; Peter Brossart [Allemagne] ; Dominik Wolf [Allemagne]Source :
- European Journal of Haematology [ 0902-4441 ] ; 2016-08.
Abstract
Introduction: Human coronavirus NL63 (HCoV‐NL63) is one of four common human respiratory coronaviruses. Despite high incidence, HCoV infections are grossly understudied. We here report a case of HCoV infection in a leukemia patient with fatal ARDS despite successful virus elimination by pegylated interferon‐alpha (PEG‐IFN‐α). Case: The 27‐year‐old female pre‐T‐ALL patient was treated according to the German‐Multicenter Trial for Adult ALL protocol. No relevant infectious complications were seen until day 35 when the neutropenic patient developed fever without any clinical focus. Antibiotic prophylaxis was switched to meropenem. The patient deteriorated rapidly with respiratory failure due to ARDS. Anti‐infectious therapy was escalated to additional linezolid and liposomal amphotericine‐B. BAL revealed a significant viral load of HCoV‐NL63. Based on successful application of PEG‐IFN against the related SARS coronavirus in animal experiments, a single injection of 180 μg PEG‐IFN‐α2b was applied. Despite immediate initiation of treatment and elimination of virus in subsequent tests, the progressive lung failure led to death 7 d after onset of fever with massive lung bleeding as a consequence of diffuse alveolar hemorrhage. Conclusion: This report emphasizes the fatal consequences of common respiratory virus infections in immunocompromised patients. HCoV‐NL63 replication can be reduced by treatment with peg‐IFN if diagnosed early.
Url:
DOI: 10.1111/ejh.12744
Affiliations:
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Despite high incidence, HCoV infections are grossly understudied. We here report a case of HCoV infection in a leukemia patient with fatal ARDS despite successful virus elimination by pegylated interferon‐alpha (PEG‐IFN‐α). Case: The 27‐year‐old female pre‐T‐ALL patient was treated according to the German‐Multicenter Trial for Adult ALL protocol. No relevant infectious complications were seen until day 35 when the neutropenic patient developed fever without any clinical focus. Antibiotic prophylaxis was switched to meropenem. The patient deteriorated rapidly with respiratory failure due to ARDS. Anti‐infectious therapy was escalated to additional linezolid and liposomal amphotericine‐B. BAL revealed a significant viral load of HCoV‐NL63. Based on successful application of PEG‐IFN against the related SARS coronavirus in animal experiments, a single injection of 180 μg PEG‐IFN‐α2b was applied. Despite immediate initiation of treatment and elimination of virus in subsequent tests, the progressive lung failure led to death 7 d after onset of fever with massive lung bleeding as a consequence of diffuse alveolar hemorrhage. Conclusion: This report emphasizes the fatal consequences of common respiratory virus infections in immunocompromised patients. HCoV‐NL63 replication can be reduced by treatment with peg‐IFN if diagnosed early.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Bonn</li></settlement></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Mayer, Karin" sort="Mayer, Karin" uniqKey="Mayer K" first="Karin" last="Mayer">Karin Mayer</name></region><name sortKey="Brossart, Peter" sort="Brossart, Peter" uniqKey="Brossart P" first="Peter" last="Brossart">Peter Brossart</name><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><name sortKey="Eis Binger, Anna M" sort="Eis Binger, Anna M" uniqKey="Eis Binger A" first="Anna M." last="Eis-Hübinger">Anna M. Eis-Hübinger</name><name sortKey="Hahn St, Corinna" sort="Hahn St, Corinna" uniqKey="Hahn St C" first="Corinna" last="Hahn-Ast">Corinna Hahn-Ast</name><name sortKey="Mayer, Karin" sort="Mayer, Karin" uniqKey="Mayer K" first="Karin" last="Mayer">Karin Mayer</name><name sortKey="Nellessen, Cordula" sort="Nellessen, Cordula" uniqKey="Nellessen C" first="Cordula" last="Nellessen">Cordula Nellessen</name><name sortKey="Pietzonka, Sandra" sort="Pietzonka, Sandra" uniqKey="Pietzonka S" first="Sandra" last="Pietzonka">Sandra Pietzonka</name><name sortKey="Schumacher, Martin" sort="Schumacher, Martin" uniqKey="Schumacher M" first="Martin" last="Schumacher">Martin Schumacher</name><name sortKey="Wolf, Dominik" sort="Wolf, Dominik" uniqKey="Wolf D" first="Dominik" last="Wolf">Dominik Wolf</name><name sortKey="Wolf, Dominik" sort="Wolf, Dominik" uniqKey="Wolf D" first="Dominik" last="Wolf">Dominik Wolf</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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